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​業績

​​血液再生制御研究室から発信する研究成果を紹介します

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研究論文

プレゼンテーション

学会発表

* : equal contribution, # : corresponding author

  • Atsuo Suzuki, Nobuaki Suzuki, Takeshi Kanematsu, Shuichi Okamoto, Naruko Suzuki, Shogo Tamura, Ryosuke Kikuchi, Akira Katsumi, Tetsuhito Kojima, Tadashi Matsushita. Variability in combinations of APTT reagent and substrate plasma for a one-stage clotting assay to measure factor VIII products. International Journal of Laboratory Hematology. 2024. In press.

  • Hinako Notoh, Satoshi Yamasaki, Nobuaki Suzuki, Atsuo Suzuki, Shuichi Okamoto, Takeshi Kanematsu, Naruko Suzuki, Akira Katsumi, Tetsuhito Kojima, Tadashi Matsushita, Shogo Tamura #. Basement membrane extract potentiates the endochondral ossification phenotype of bone marrow-derived mesenchymal stem cell-based cartilage organoids. Biochemical and Biophysical Research Communications. Volume 701, 15 March 2024, 149583. DOI: https://doi.org/10.1016/j.bbrc.2024.149583

  • Yukino Kojima, Fumika Kawashima, Takahiko Yasuda, Koya Odaira, Yuichiro Inagaki, Chiharu Yamada, Ami Muraki, Mina Noura, Shuichi Okamoto, Shogo Tamura, Eisuke Iwamoto, Masashi Sanada, Itaru Matsumura, Yasushi Miyazaki, Tetsuhito Kojima, Hitoshi Kiyoi, Shinobu Tsuzuki, Fumihiko Hayakawa. EBF1-JAK2 inhibits the PAX5 function through physical interaction with PAX5 and kinase activity. Int J Hematol. 2023 Jul;118(1):65-74. doi: 10.1007/s12185-023-03585-z.

  • Naruko Suzuki, Nobuaki Suzuki, Yuka Kawaguchi, Shuichi Okamoto, Takeshi Kanematsu, Akira Katsumi, Atsuo Suzuki, Shogo Tamura, Tetsuhito Kojima, Hitoshi Kiyoi, Tadashi Matsushita. The usefulness of tranexamic acid for bleeding symptoms of chronic consumptive coagulopathy complicated by aortic disease: A single-institute, retrospective study of 14 patients. Thrombosis Journal. 2022. Jan 25;21(1):10. doi: 10.1186/s12959-022-00429-4.

  • Odaira Koya, Yasuda Takahiko, Okada Kentaro, Shimooka Takuya, Kojima Yukino, Noura Mina, Shogo Tamura, Kurahashi Shingo, Iwamoto Eisuke, Sanada,Masashi, Matsumura Itaru, Miyazaki Yasushi, Kojima Tetsuhito, Kiyoi Hitoshi, Tsuzuki Shinobu, Hayakawa Fumihiko. Functional inhibition of MEF2 by C/EBP is a possible mechanism of leukemia development by CEBP-IGH fusion gene. Cancer science. 2022. Mar;114(3):781-792. doi: 10.1111/cas.15641.

  • 鈴木 伸明, 兼松 毅, 岸本 磨由子, 鈴木 奈瑠子, 岡本 修一, 田村 彰吾, 清井 仁, 松下 正. 2022. 血液凝固第IX因子濃縮製剤へのアレルギーに対する減感作療法の有効性. 日本輸血細胞治療学会誌. 68 巻 3 号 p. 422-427.

  • Keiji Nogami, Masashi Taki, Tadashi Matsushita, Tetsuhito Kojima, Toshiaki Oka, Shouichi Ohga, Kiyoshi Kawakami, Michio Sakai, Takashi Suzuki, Satoshi Higasa, Yasuo Horikoshi, Keiko Shinozawa, Shogo Tamura, Koji Yada, Masue Imaizumi, Yoshitoshi Otsuka, Fuminori Iwasaki, Masao Kobayashi, Junki Takamatsu, Hideyuki Takedani, Hisaya Nakadate, Yoko Matsuo, Takeshi Matsumoto, Teruhisa Fujii, Katsuyuki Fukutake, Akira Shirahata, Akira Yoshioka, Midori Shima, on behalf of the J-HIS2 study group. 2022. Clinical situations and risk factors of inhibitor development in the patients with hemophilia from a decade-long prospective cohort study in Japan, J-HIS2 (Japan Hemophilia Inhibitor Study 2). Haemophilia. 28(5):745-759. DOI: 10.1111/hae.14602

  • Shuichi Okamoto, Shogo Tamura, Naomi Sanda, Koya Odaira, Yuri Hayakawa, Masato Mukaide, Atsuo Suzuki, Takeshi Kanematsu, Fumihiko Hayakawa, Akira Katsumi, Hitoshi Kiyoi, Tetsuhito Kojima, Tadashi Matsushita, Nobuaki Suzuki. 2022. VWF-Gly2752Ser, a novel non-cysteine substitution variant in the CK domain, exhibits severe secretory impairment by hampering C-terminal dimer formation. Journal of Thrombosis and Haemostasis. 20(8):1784-1796. DOI: 10.1016/j.jstrokecerebrovasdis.2022.106526 （掲載号の表紙に採用）

  • Masahiro Nishihori, Yoshio Araki, Nobuaki Suzuki, Shogo Tamura, Mayo Hattori, Takashi Izumi, Shunsaku Goto, Kinya Yokoyama, Kenji Uda, Tadashi Matsushita, Ryuta Saito. 2022. Medical management of a mural thrombus inducing repeated ischemic strokes in a patient with congenital afibrinogenemia Journal of Stroke and Cerebrovascular Diseases. 31(7):106526. DOI:10.1016/j.jstrokecerebrovasdis.2022.106526

  • Shogo Tamura #, Masato Mukaide, Yumi Katsuragi, Wataru Fujii, Koya Odaira, Nobuaki Suzuki, Nagaharu Tsukiji, Shuichi Okamoto, Atsuo Suzuki, Takeshi Kanematsu, Akira Katsumi, Akira Takagi, Katsuhide Ikeda, Jun Ueyama, Masaaki Hirayama, Katsue Suzuki-Inoue, Tadashi Matsushita, Tetsuhito Kojima, Fumihiko Hayakawa. 2022. Periosteum-derived podoplanin-expressing stromal cells regulate nascent vascularization during epiphyseal marrow development. Journal of Biological Chemistry. 298(5):101833. DOI: 10.1016/j.jbc.2022.101833

  • Koya Odaira *, Fumika Kawashima *, Shogo Tamura #, Nobuaki Suzuki, Mahiru Tokoro, Yuri Hayakawa, Atsuo Suzuki, Takeshi Kanematsu, Shuichi Okamoto, Akira Takagi, Akira Katsumi, Tadashi Matsushita, Midori Shima, Keiji Nogami, Tetsuhito Kojima, Fumihiko Hayakawa. 2022. F9 mRNA splicing aberration due to a deep Intronic structural variation in a patient with moderate hemophilia B. 213: 91-96. DOI: 10.1016/j.thromres.2022.03.010

  • Kentaro Okada *, Shogo Tamura *, #, Nobuaki Suzuki, Koya Odaira, Masato Mukaide, Wataru Fujii, Yumi Katsuragi, Atsuo Suzuki, Takeshi Kanematsu, Shuichi Okamoto, Naruko Suzuki, Akira Katsumi, Tadashi Matsushita, Tetsuhito Kojima, Fumihiko Hayakawa. 2022. "Protein S-Leu17Pro disrupts the hydrophobicity of its signal peptide causing a proteasome-dependent degradation." Thrombosis Research. 210: 26-32. DOI: 10.1016/j.thromres.2021.12.014

  • Atsuo Suzuki, Nobuaki Suzuki, Takeshi Kanematsu, Sho Shinohara, Hiroshi Kurono, Nobuo Arai, Shuichi Okamoto, Naruko Suzuki, Shogo Tamura, Ryosuke Kikuchi, Akira Katsumi, Tetsuhito Kojima & Tadashi Matsushita. 2022. Development and validation of a novel qualitative test for plasma fibrinogen utilizing clot waveform analysis. Scientific Reports. 12(1):1-9. DOI: 10.1038/s41598-021-04464-5

  • Akira Katsumi, Akihiro Abe, Shogo Tamura, Tadashi Matsushita. 2021. "Anemia in older adults as a geriatric syndrome: A review".  Geriatrics and Gerontology International. 21(7): 549-554. DOI: 10.1111/ggi.14183

  • Shimon Otake, Tomoyuki Sasaki, Toshiaki Shirai, Nagaharu Tsukiji, Shogo Tamura, Katsuhiro Takano, Yukio Ozaki, Katsue Suzuki-Inoue. 2021. "CLEC-2 stimulates IGF-1 secretion from podoplanin-positive stromal cells and positively regulates erythropoiesis in mice". Journal of Thrombosis and Haemostasis. 19(6): 1572-1584. doi:10.1111/jth.15317

  • Yuri Hayakawa, Shogo Tamura #, Nobuaki Suzuki, Koya Odaira, Mahiru Tokoro, Fumika Kawashima, Fumihiko Hayakawa, Akira Takagi, Akira Katsumi, Atsuo Suzuki, Shuichi Okamoto, Takeshi Kanematsu, Tadashi Matsushita, and Tetsuhito Kojima. 2021. "Essential role of a carboxyl-terminal α-helix motif in the secretion of coagulation factor XI". Journal of Thrombosis and Haemostasis. 19(4): 920-930. DOI: 10.1111/jth.15242（掲載号の表紙に採用）

  • Takeshi Kanematsu, Nobuaki Suzuki, Shogo Tamura, Atsuo Suzuki, Yuichi Ishikawa, Akira Katsumi, Hitoshi Kiyoi, Hidehiko Saito, Shinji Kunishima, Tetsuhito Kojima, Tadashi Matsushita. 2021. "Myh9 R702C is associated with erythroid abnormality with splenomegaly in mice". Nagoya Journal of Medical Science. 83. 75–86. doi:10.18999/nagjms.83.1.75

  • Atsuo Suzuki, Nobuaki Suzuki, Takeshi Kanematsu, Shuichi Okamoto, Shogo Tamura, Ryosuke Kikuchi, Akira Katsumi, Hitoshi Kiyoi, Tetsuhito Kojima, Tadashi Matsushita. 2020. "Impact of variation in reagent combinations for one‐stage clotting assay on assay discrepancy in nonsevere haemophilia A". International journal of laboratory hematology. 43(1): 131-138.  https://doi.org/10.1111/ijlh.13335

  • 鈴木敦夫，鈴木伸明，兼松 毅，岡本修一，田村彰吾，篠原 翔， 新井信夫，菊地良介，安藤善孝，小嶋哲人，松下 正. 2020.  "血小板膜糖蛋白質GPIb変異体を用いたvon Willebrand因子 活性測定試薬「INNOVANCE® VWF Ac」の基本性能評価". 日本血栓止血学会誌 31(4): 409-419. https://doi.org/10.2491/jjsth.31.409

  • Tokoro M *, Tamura S *,  #, Suzuki N, Kakihara M, Hattori Y, Odaira K, Suzuki S, Takagi A, Katsumi A, Hayakawa F, Okamoto S, Suzuki A, Kanematsu T, Matsushita T, Kojima T. 2020. "Aberrant X chromosomal rearrangement through multi-step template switching during sister chromatid formation in a patient with severe hemophilia A". Molecular Genetics and Genomic Medicine 8(9) e1390. https://doi.org/10.1002/mgg3.1390

  • 田村彰吾 #、高木明、早川文彦、小嶋哲人. 2020. “先天性凝固異常症の遺伝子解析 「解析のStrategyとPitfall」” 日本検査血液学会雑誌 21 (1): 71–80.

  • Ogawa M, Suzuki N, Takahashi N, Tamura S, Suzuki A, Suzuki S, Hattori Y, Kakihara M, Kanematsu, T, Kojima, Toshihisa, Katsumi A, Hayakawa F, Kojima Tetsuhito, Ishiguro N, Kiyoi H, Matsushita T. 2020. “Higher FVIII:C Measured by Chromogenic Substrate Assay than by One-Stage Assay Is Associated with Silent Hemophilic Arthropathy.” Thrombosis Research 188 (January): 103–5. DOI: 10.1016/j.thromres.2020.01.003

  • Inoue O, Osada M, Nakamura J, Kazama F, Shirai T, Tsukiji N, Sasaki T, Yokomichi H, Dohi T, Kaneko M, Kurano M, Oosawa M, Tamura S, Satoh K, Takano K, Miyauchi K, Daida H, Yatomi Y, Ozaki Y, Suzuki-Inoue K. 2019. “Soluble CLEC-2 Is Generated Independently of ADAM10 and Is Increased in Plasma in Acute Coronary Syndrome: Comparison with Soluble GPVI.” International Journal of Hematology 110(3):285-294. https://doi.org/10.1007/s12185-019-02680-4.

  • Tamura S *, #, Hashimoto E *, Suzuki N, Kakihara M, Odaira K, Hattori Y, Tokoro M, Sachiko S, Takagi A, Katsumi A, Hayakawa F, Suzuki A, Okamoto S, Kanematsu T, Matsushita T, Kojima T. 2019. “Molecular Basis of SERPINC1 Mutations in Japanese Patients with Antithrombin Deficiency.” Thrombosis Research 178 (April): 159–70. DOI: 10.1016/j.thromres.2019.04.004.

  • Odaira K *, Tamura S *, #, Suzuki N, Kakihara M, Hattori Y, Tokoro M, Suzuki S, Takagi A, Katsumi A, Hayakawa F, Okamoto S, Suzuki A, Kanematsu T, Matsushita T, Kojima T. 2019. “Apparent Synonymous Mutation F9 c.87A>G Causes Secretion Failure by in-Frame Mutation with Aberrant Splicing.” Thrombosis Research 179 (April): 95–103.  DOI: 10.1016/j.thromres.2019.04.022.

  • Okamoto S,  Suzuki N, Suzuki A, Suzuki S, Tamura S, Suzuki M, Takahashi N, Kojima Toshihisa, Kanematsu T, Kojima, Tetsuhito, Kiyoi H, Ishiguro N, Matsushita T. 2019. “Successful Perioperative Combination of High-Dose FVIII Therapy Followed by Emicizumab in a Patient with Hemophilia A with Inhibitors.” TH Open 3 (4): e364–66.  DOI: 10.1055/s-0039-3401001.

  • Tamura S, Suzuki-Inoue K, Ozaki Y, Hayakawa F, Kojima T. 2019. “[Peri-Arteriolar Megakaryopoietic Microenvironment via Reciprocal CLEC-2/PDPN Axis in Bone Marrow].” [Rinsho Ketsueki] The Japanese Journal of Clinical Hematology 60 (7): 834–42.  DOI: 10.11406/rinketsu.60.834.（掲載号の表紙に採用）

  • 田村彰吾 #. 2018. “マウス骨髄の Podoplanin 陽性傍細動脈間質細胞は CLEC-2 を介して巨核球系細胞の増殖と Proplatelet Formation を促進する.” 日本血栓止血学会誌 29 (4): 389–97.  DOI: 10.2491/jjsth.29.389.

  • Tsukiji N, Inoue O, Morimoto M, Tatsumi N, Nagatomo H, Ueta K, Shirai T, Sasaki T, Otake S, Tamura S, Tachibana T, Okabe M, Hirashima M, Ozaki Y, Suzuki-Inoue K. 2018. “Platelets Play an Essential Role in Murine Lung Development through Clec-2/Podoplanin Interaction.” Blood 132 (11): 1167–79.  DOI: 10.1182/blood-2017-12-823369.（掲載号の表紙に採用）

  • Sasaki T, Shirai T, Tsukiji N, Otake S, Tamura S, Ichikawa J, Osada M, Satoh K, Ozaki Y, Suzuki-Inoue K. 2018. “Functional Characterization of Recombinant Snake Venom Rhodocytin: Rhodocytin Mutant Blocks CLEC-2/Podoplanin-Dependent Platelet Aggregation and Lung Metastasis.” Journal of Thrombosis and Haemostasis 16 (5): 960–72.  DOI: 10.1111/jth.13987.

  • Tamura S, Suga Y, Tanamura M, Murata-Kawakami M, Takagi Y, Hottori Y, Kakihara M, Suzuki S, Takagi A, Kojima T. 2018. “Optimisation of Antithrombin Resistance Assay as a Practical Clinical Laboratory Test: Development of Prothrombin Activator Using Factors Xa/Va and Automation of Assay.” International Journal of Laboratory Hematology 40 (3): 312–19.  DOI: 10.1111/ijlh.12786.

  • Suzuki S, Nakamura Y, Suzuki N, Yamazaki T, Takagi Y, Tamura S, Takagi A, Kanematsu T, Matsushita T, Kojima T. 2018. “Combined Deficiency of Factors V and VIII by Chance Coinheritance of Parahaemophilia and Haemophilia A, but Not by Mutations of Either LMAN1 or MCFD2, in a Japanese Family.” Haemophilia 24 (1): e13–16.  DOI: 10.1111/hae.13360. 

  • 高木明、田村彰吾、小嶋哲人. 2018. "アンチトロンビン抵抗性の診断 - 検査法を中心に -". 日本検査血液学会雑誌 19(3): 393-400. 

  • Kamiyama M, Shirai T, Tamura S, Suzuki-Inoue K, Ehata S, Takahashi K, Miyazono K, Hayakawa Y,

  • Sato T, Takeda K, Naguro I, Ichijo H. 2017. “ASK1 Facilitates Tumor Metastasis through Phosphorylation of an ADP Receptor P2Y12 in Platelets.” Cell Death and Differentiation 24 (12): 2066–76.  DOI: 10.1038/cdd.2017.114.

  • Furuya F, Ishii T, Tamura S, Takahashi, Kobayashi H, Ichijo M, Takizawa S, Kaneshige M, Suzuki-Inoue K, and Kitamura K. 2017. “The Ligand-Bound Thyroid Hormone Receptor in Macrophages Ameliorates Kidney Injury via Inhibition of Nuclear Factor-ΚB Activities.” Scientific Reports 7 (March): 43960.  DOI: 10.1038/srep43960.

  • 田村彰吾 #、尾崎由基男、小嶋哲人、井上克枝. 2017. “血小板・巨核球造血微小環境を構成する骨髄間質細胞.” 日本血栓止血学会誌 28 (1): 59–63. DOI: https://doi.org/10.2491/jjsth.28.59.

  • Tamura S, Murata-Kawakami M, Takagi Y, Suzuki S, Katsumi A, Takagi A, Kojima T. 2017. “In Vitro Exploration of Latent Prothrombin Mutants Conveying Antithrombin Resistance.” Thrombosis Research 159 (August): 33–38.  DOI: 10.1016/j.thromres.2017.09.020.

  • 田村彰吾 #、井上克枝、小嶋哲人. 2017. “２．巨核球造血の微小環境.” 血液フロンティア 27 (6): 37–46.

  • Shirai T,  Inoue O, Tamura S, Tsukiji N, Sasaki T, Endo H, Satoh K, Osada M, Sato-Uchida H, Fujii H,  Ozaki Y, Suzuki-Inoue K. 2016. “CLEC-2 Promotes Hematogenous Tumor Metastasis and Prothrombotic State in Tumor-Bearing Mice.” Journal of Thrombosis and Haemostasis 38 (1): 42–49.  DOI: 10.1111/jth.13604.

  • Ozaki Y, Tamura S, Suzuki-Inoue K. 2016. “New Horizon in Platelet Function: With Special Reference to a Recently-Found Molecule, CLEC-2.” Thrombosis Journal 14 (Suppl 1): 27.  DOI: 10.1186/s12959-016-0099-8.

  • Takagi Y, Murata M, Kozuka T, Nakata Y, Hasebe R, Tamura S, Takagi A, Matsushita T, Saito H, Kojima T. 2016. “Missense Mutations in the Gene Encoding Prothrombin Corresponding to Arg596 Cause Antithrombin Resistance and Thrombomodulin Resistance.” Thrombosis and Haemostasis 116 (6): 1–10.  DOI: 10.1160/TH16-03-0223.

  • Kozuka T, Tamura S, Kawamura N, Nakata Y, Hasebe R, Makiyama A, Takagi Y, Murata M, Mizutani N, Takagi A, Kojima T. 2016. “Progestin Isoforms Provide Different Levels of Protein S Expression in HepG2 Cells.” Thrombosis Research 145 (September): 40–45.  DOI: 10.1016/j.thromres.2016.07.007.

  • Tamura S, Suzuki-Inoue K, Tsukiji N, Shirai T, Sasaki T, Osada M, Satoh K, Ozaki Y. 2016. “Podoplanin-Positive Periarteriolar Stromal Cells Promote Megakaryocyte Growth and Proplatelet Formation in Mice by CLEC-2.” Blood 127 (13): 1701–10.  DOI: 10.1182/blood-2015-08-663708.（掲載号の表紙に採用）

  • Masuda Y*, Tamura S*, Matsuno K, Nagasawa A, Hayasaka K, Shimizu C, Moriyama T. 2015. “Diverse CD36 Expression among Japanese Population: Defective CD36 Mutations Cause Platelet and Monocyte CD36 Reductions in Not Only Deficient but Also Normal Phenotype Subjects.” Thrombosis Research 135 (5): 951–57.  DOI: 10.1016/j.thromres.2015.03.002.

  • Kazama F, Nakamura N, Osada M, Inoue O, Oosawa M, Tamura S, Tsukiji N, Aida K, Kawaguchi A, 

  • Takizawa S, Kaneshige M, Tanaka S, Suzuki-Inoue K,Ozaki Y. 2015. “Measurement of Soluble C-Type Lectin-like Receptor 2 in Human Plasma.” Platelets 26 (8): 711–19.  DOI: 10.3109/09537104.2015.1021319.

  • Moriyama T, Tamura S, Nakano K, Otsuka K, Shigemura M, Honma N. 2015. “Laboratory and Clinical Features of Abnormal Macroenzymes Found in Human Sera.” Biochimica et Biophysica Acta 1854 (6): 658–67.  DOI: 10.1016/j.bbapap.2014.10.015.

  • Nagasawa, A, Matsuno K, Tamura S, Hayasaka K, Shimizu C, and Moriyama T. 2013. “The Basis Examination of Leukocyte-Platelet Aggregates with CD45 Gating as a Novel Platelet Activation Marker.” International Journal of Laboratory Hematology 35 (5): 534–41.  DOI: 10.1111/ijlh.12051.

  • Nakano K, Tamura S, Otuka K, Niizeki N, Shigemura N, Shimizu C, Matsuno K, Kobayashi S, Moriyama T. 2013. “Development of a Highly Sensitive Three-Dimensional Gel Electrophoresis Method for Characterization of Monoclonal Protein Heterogeneity.” Analytical Biochemistry 438 (2): 117–23.  DOI: 10.1016/j.ab.2013.03.013.

  • Nozaki R, Tamura S, Ito A, Moriyama T, Yamaguchi K, Kono T. 2012. “A Rapid Method to Isolate Soluble Royal Jelly Proteins.” Food Chemistry 134 (4): 2332–37.  DOI: 10.1016/j.foodchem.2012.03.106.

  • Tamura S, Nagasawa A, Masuda Y, Tsunematsu T, Hayasaka K, Matsuno M, Shimizu C, Ozaki O, Moriyama T. 2012. “BDNF, Produced by a TPO-Stimulated Megakaryocytic Cell Line, Regulates Autocrine Proliferation.” Biochemical and Biophysical Research Communications 427 (3): 542–46.  DOI: 10.1016/j.bbrc.2012.09.093.

  • Tamura S, Suzuki H, Hirowatari Y, Hatase M, Nagasawa A, Matsuno K, Kobayashi S, Moriyama T. 2011. “Release Reaction of Brain-Derived Neurotrophic Factor (BDNF) through PAR1 Activation and Its Two Distinct Pools in Human Platelets.” Thrombosis Research 128 (5): e55-61.  DOI: 10.1016/j.thromres.2011.06.002.

  • Tamura S, Amano S, Kono K, Kondoh J, Yamaguchi K, Kobayashi S, Ayabe T, Moriyama T. 2009. “Molecular Characteristics and Physiological Functions of Major Royal Jelly Protein 1 Oligomer.” Proteomics 9 (24): 5534–43.  DOI: 10.1002/pmic.200900541.

  • Tamura S, Kono T, Harada C, Yamaguchi K, Moriyama T. 2009. “Estimation and Characterisation of Major Royal Jelly Proteins Obtained from the Honeybee Apis Merifera.” Food Chemistry 114 (4): 1491–97.  DOI: 10.1016/j.foodchem.2008.11.058.

2023年

第45回日本血栓止血学会学術集会

  • O-019/P-011　田村彰吾、桂木裕実、鈴木伸明、岡本修一、藤井渉、鈴木敦夫、兼松毅、鈴木奈瑠子、能藤日向子、山崎智司、小嶋哲人、松下正、早川文彦「先天性無フィブリノゲン血症2症例に同定したFGA exon 4 のホモ接合体欠失」

第57回日本臨床検査医学会北海道支部総会・第33回日本臨床化学会北海道支部例会

  • 田村彰吾、鈴木伸明、岡本修一、鈴木敦夫、兼松毅、鈴木奈瑠子、能藤日向子、山崎智司、小嶋哲人、松下正「FGA exon 4 欠失ホモ接合体を原因とした先天性無フィブリノゲン血症の3症例」

  • 能藤日向子，山崎智司、鈴木伸明、岡本修一、鈴木敦夫、兼松毅、鈴木奈瑠子、小嶋哲人、松下正、田村彰吾「骨髄ポドプラニン陽性間質細胞の時空間的骨髄組織内変移の解明」

  • 山崎智司、藤井渉、能藤日向子、鈴木伸明、岡本修一、鈴木敦夫、兼松毅、鈴木奈瑠子、小嶋哲人、松下正、田村彰吾「先天性アンチトロンビン欠乏症家系に発見した新規SERPINC1バリアント AT-I218F の分子病態解析」

​

2021年

第43回日本血栓止血学会学術集会

  • O-019/P-011　鈴木敦夫，鈴木伸明，兼松毅，岡本修一，田村彰吾，小嶋哲人，松下正　「第 VIII 因子製剤の活性測定における試薬バリエーションを把握するための単施設研究」

  • O-028　鈴木伸明，鈴木敦夫，田村彰吾，向出将人，岡本修一，兼松毅，小嶋哲人，松下正　「マウス血管結紮モデルによるアンチトロンビンレジスタンスの血栓形成解析」

  • O-036/P-040　岡田健太郎，田村彰吾，鈴木伸明，大平晃也，早川友梨，向出将人，藤井渉，桂木裕実，兼松毅，岡本　修一，鈴木敦夫，松下正，小嶋哲人，早川文彦　「プロテイン S 欠乏症に同定したシグナルペプチド内変異プロテイン S の分子病態解析」

  • P-002 向出将人，田村彰吾，鈴木伸明，大平晃也，早川友梨，岡田健太郎，藤井渉，桂木裕実，鈴木敦夫，兼松毅，岡本　修一，松下正，小嶋哲人，早川文彦　「フィブリノゲン強制発現系の最適化に向けた基礎検討」

  • P-004　大平晃也，早川友梨，田村彰吾，鈴木伸明，所真昼，河島史華，向出将人，岡田健太郎，桂木裕実，藤井渉，岡本修一，兼松毅，鈴木敦夫，松下正，小嶋哲人，早川文彦　「F8 Int22h-1 が関与する F8 大規模欠失挿入変異による重症血友病 A 症例」

  • P-017 　兼松毅，鈴木伸明，岡本修一，鈴木敦夫，田村彰吾，早川文彦，小嶋哲人，清井仁，松下正「周術期の止血に難渋した先天性第 V 因子欠乏症の 1 例」

  • P-061　岡本修一，大平晃也，早川友梨，河島史華，田村彰吾，鈴木伸明，兼松毅，鈴木敦夫，早川文彦，清井仁，小嶋　哲人，松下正「VWF G2752S 変異体の分子病態解析」

2023年

  • 能藤日向子 (大学院博士前期課程1年)　ibidi社フォトコンテスト日本大会 特別賞

2021年

  • 向出将人 (大学院博士前期課程2年)　公益財団法人大幸財団 第 41 回学芸奨励生

  • 向出将人 (大学院博士前期課程2年)　第43回日本血栓止血学会学術集会優秀ポスター賞 「フィブリノゲン強制発現系の最適化に向けた基礎検討 (P-002)」 2021年5月28日

  • 岡田健太郎 (大学院博士前期課程2年)　第43回日本血栓止血学会学術集会優秀ポスター賞 「プロテイン S 欠乏症に同定したシグナルペプチド内変異プロテイン S の分子病態解析 (P-040)」2021年5月28日

 2020年

  • 早川友梨 (大学院博士前期課程2年)　第42回日本血栓止血学会学術集会優秀ポスター賞 「C末端伸長変異型Factor XIにおける分泌異常の解析 (P-001)」2020年6月20日

  • 早川友梨 (大学院博士前期課程2年)　第82回日本血液学会学術集会優秀ポスター賞 「Critical role of carboxyl-terminalα-helix in secretion of coagulation factor XI (PS-44-8 A)」2020年10月9日

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